Poor outcomes of chronic active Epstein-Barr virus infection and hemophagocytic lymphohistiocytosis in non-Japanese adult patients.
نویسندگان
چکیده
Chronic active Epstein-Barr virus infection manifests as a combination of persistent infectious mononucleosis-like symptoms and high viral load in apparently immunocompetent patients. It is closely related to Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. These 2 abnormal Epstein-Barr virus-associated diseases are seldom reported in individuals other than Japanese children and adolescents. We report a series of 2 adult non-Japanese patients with fatal chronic active Epstein-Barr virus and 1 adult non-Japanese patient with Epstein-Barr virus hemophagocytic lymphohistiocytosis and discuss its pathogenesis and treatment options.
منابع مشابه
Guillain-Barré syndrome and hemophagocytic lymphohistiocytosis in a patient with severe chronic active Epstein-Barr virus infection syndrome.
Epstein-Barr virus (EBV) infection causes a wide range of neurologic and hematologic manifestations. We report a 72-year-old Japanese male patient with severe chronic active EBV infection syndrome (SCAEBV) who presented with Guillain-Barré syndrome (GBS) and developed hemophagocytic lymphohistiocytosis (HLH) several months after the onset of GBS. He showed acute onset of distal muscle weakness,...
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متن کاملAbbreviations: BM: bone marrow, CAEBV: chronic active Epstein-Barr virus infection, EBV: Epstein-Barr virus, EBER: Epstein-Barr virus-encoded mRNA, EBNA: Epstein-Barr virus-nuclear antigen, HLH: hemophagocytic lymphohistiocytosis, HIV: human immunodeficiency virus, HMB: hypersensitivity to mosquito
Affiliations: 1. Department of Pediatrics, 2. Department of Medicine and Biosystemic Science, 3. Department of Medicine, and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 4. Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, 5. Department of 2 Pathology, Faculty of Medicine, Kurume University School o...
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ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 47 1 شماره
صفحات -
تاریخ انتشار 2008